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As the primary defense against invaders from outside and inside the body, the importance of the immune system cannot be overstated

The systematic review of Voroneanu et al

Although reference ranges vary between laboratories, evidence suggests that disease risk begins to increase well before homocysteine reaches the traditional upper limit of 15 mol/L

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For a supplement to be effective, it needs to bypass the destructive environment of the stomach and the "first-pass metabolism" of the liver